Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells

Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells

Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) in various immune cell types. CD73, a key enzymatic regulator responsible for adenosine production, is frequently ove...

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Main Authors: Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/3/e008594.full
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https://jitc.bmj.com/content/13/3/e008594.full

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