Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression

Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression

Abstract Osteocalcin (OCN) is an endocrine hormone that signals in the periphery, regulating male fertility, energy expenditure and glucose homeostasis. It can also cross the blood-brain-barrier and act on the brain via receptors GPR37 and GPR158. In the brain, OCN influences neurotransmitter synthe...

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Bibliographic Details
Main Authors: Natalia K. Freus, Isabel Wank, Maximilian Häfele, Liubov S. Kalinichenko, Christian P. Müller, Sandra Strobelt, Andreas Ludwig, Andreas Hess, Silke Kreitz
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Osteocalcin
Mouse fMRI
Functional connectivity
rCBV
Depression
Allen brain atlas
Online Access:https://doi.org/10.1038/s41598-025-95000-2
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https://doi.org/10.1038/s41598-025-95000-2

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