Differentiating Main-Duct IPMN from Chronic Pancreatitis Using Next-Generation Sequencing of Main Pancreatic Duct Fluid: A Pilot Study

Differentiating Main-Duct IPMN from Chronic Pancreatitis Using Next-Generation Sequencing of Main Pancreatic Duct Fluid: A Pilot Study

<b>Background</b>: A dilated main pancreatic duct (MPD) ≥ 5 mm can be observed in main-duct IPMNs (MD-IPMN) and chronic pancreatitis (CP); however, distinguishing between the two differently treated diseases can be difficult. Cell-free (cf) DNA in MPD fluid obtained by EUS-guided FNA mig...

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Main Authors: Daniel Schmitz, Stefan Prax, Martin Kliment, Felix Gocke, Daniel Kazdal, Michael Allgäuer, Roland Penzel, Martina Kirchner, Olaf Neumann, Holger Sültmann, Jan Budczies, Peter Schirmacher, Frank Bergmann, Jörg-Peter Ritz, Raoul Hinze, Felix Grassmann, Jochen Rudi, Albrecht Stenzinger, Anna-Lena Volckmar
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Diagnostics
Subjects:
intraductal papillary mucinous neoplasm
pancreatitis
chronic
endoscopic ultrasound-guided fine needle aspiration
high-throughput nucleotide sequencing
prospective study
Online Access:https://www.mdpi.com/2075-4418/15/15/1964
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