Manipulation of the Complement System for Benefit in Sepsis
There is evidence in sepsis, both in rodents and in humans, that activation of the complement system results in excessive production of C5a, which triggers a series of events leading to septic shock, multiorgan failure, and lethality. In rodents following cecal ligation and puncture (CLP), which in...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/427607 |
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| _version_ | 1832552619327881216 |
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| author | Peter A. Ward Ren-Feng Guo Niels C. Riedemann |
| author_facet | Peter A. Ward Ren-Feng Guo Niels C. Riedemann |
| author_sort | Peter A. Ward |
| collection | DOAJ |
| description | There is evidence in sepsis, both in rodents and in humans, that activation of the complement system results in excessive production of C5a, which triggers a series of events leading to septic shock, multiorgan failure, and lethality. In rodents following cecal ligation and puncture (CLP), which induces polymicrobial sepsis, in vivo blockade of C5a using neutralizing antibodies dramatically improved survival, reduced apoptosis of lymphoid cells, and attenuated the ensuing coagulopathy. Based on these data, it seems reasonable to consider therapeutic blockade of C5a in humans entering into sepsis and septic shock. Strategies for the development of such an antibody for use in humans are presented. |
| format | Article |
| id | doaj-art-17cbd0610c5e4985b3135826a5804565 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-17cbd0610c5e4985b3135826a58045652025-02-03T05:58:12ZengWileyCritical Care Research and Practice2090-13052090-13132012-01-01201210.1155/2012/427607427607Manipulation of the Complement System for Benefit in SepsisPeter A. Ward0Ren-Feng Guo1Niels C. Riedemann2Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, P.O. Box 5602, Ann Arbor, MI 48109-5602, USADepartment of Pathology, University of Michigan Medical School, 1301 Catherine Road, P.O. Box 5602, Ann Arbor, MI 48109-5602, USADepartment of Anesthesiology and Intensive Care Medicine, University Hospital Jena, 07747 Jena, GermanyThere is evidence in sepsis, both in rodents and in humans, that activation of the complement system results in excessive production of C5a, which triggers a series of events leading to septic shock, multiorgan failure, and lethality. In rodents following cecal ligation and puncture (CLP), which induces polymicrobial sepsis, in vivo blockade of C5a using neutralizing antibodies dramatically improved survival, reduced apoptosis of lymphoid cells, and attenuated the ensuing coagulopathy. Based on these data, it seems reasonable to consider therapeutic blockade of C5a in humans entering into sepsis and septic shock. Strategies for the development of such an antibody for use in humans are presented.http://dx.doi.org/10.1155/2012/427607 |
| spellingShingle | Peter A. Ward Ren-Feng Guo Niels C. Riedemann Manipulation of the Complement System for Benefit in Sepsis Critical Care Research and Practice |
| title | Manipulation of the Complement System for Benefit in Sepsis |
| title_full | Manipulation of the Complement System for Benefit in Sepsis |
| title_fullStr | Manipulation of the Complement System for Benefit in Sepsis |
| title_full_unstemmed | Manipulation of the Complement System for Benefit in Sepsis |
| title_short | Manipulation of the Complement System for Benefit in Sepsis |
| title_sort | manipulation of the complement system for benefit in sepsis |
| url | http://dx.doi.org/10.1155/2012/427607 |
| work_keys_str_mv | AT peteraward manipulationofthecomplementsystemforbenefitinsepsis AT renfengguo manipulationofthecomplementsystemforbenefitinsepsis AT nielscriedemann manipulationofthecomplementsystemforbenefitinsepsis |