Manipulation of the Complement System for Benefit in Sepsis

There is evidence in sepsis, both in rodents and in humans, that activation of the complement system results in excessive production of C5a, which triggers a series of events leading to septic shock, multiorgan failure, and lethality. In rodents following cecal ligation and puncture (CLP), which in...

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Bibliographic Details
Main Authors: Peter A. Ward, Ren-Feng Guo, Niels C. Riedemann
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Critical Care Research and Practice
Online Access:http://dx.doi.org/10.1155/2012/427607
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