Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate

Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate

Abstract Background Extragonadal follicle-stimulating hormone (FSH) receptor (FSHR) expression in various cancers and their endothelial vessel cells has highlighted novel opportunities for targeted FSHR therapy. Methods We investigated the specificity/cytotoxicity of Phor21 fusion lytic peptide, con...

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Main Authors: Nafis A. Rahman, Marcin Chrusciel, Donata Ponikwicka-Tyszko, Kamila Pulawska-Moon, Milena Doroszko, Joanna Stelmaszewska, Oliver J. Keuzer, Adolfo Rivero-Muller, Piotr Bernaczyk, Grzegorz Zalewski, Peilan Guo, Jorma Toppari, Xiangdong Li, Adam J. Ziecik, Slawomir Wolczynski, Ilpo Huhtaniemi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
FSHR
Lytic peptide
Phor21
FSHβ
Cancer
Online Access:https://doi.org/10.1186/s10020-025-01292-5
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https://doi.org/10.1186/s10020-025-01292-5

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