Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis
The global tuberculosis (TB) epidemic is becoming progressively more complex due to the increasing prevalence of multidrug-resistant TB (MDR-TB), particularly with resistance to fluoroquinolones (FQs). This study focuses on identifying genetic mutations in the gyrA and gyrB genes of Mycobacterium tu...
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Journal of Pure and Applied Microbiology
2024-12-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/mutational-insights-into-gyra-and-gyrb-genes-in-mycobacterium-tuberculosis-a-genetic-basis-for-fluoroquinolone-resistance-in-multidrug-resistant-tuberculosis/ |
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| author | Anam Shafiq Haris Manzoor Khan Mohd. Shahid Nazish Fatima Mo Ahamad Khan |
| author_facet | Anam Shafiq Haris Manzoor Khan Mohd. Shahid Nazish Fatima Mo Ahamad Khan |
| author_sort | Anam Shafiq |
| collection | DOAJ |
| description | The global tuberculosis (TB) epidemic is becoming progressively more complex due to the increasing prevalence of multidrug-resistant TB (MDR-TB), particularly with resistance to fluoroquinolones (FQs). This study focuses on identifying genetic mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis that drive FQ resistance. Sputum samples from suspected pulmonary TB patients were analyzed using PCR and sequencing to detect mutations within the quinolone resistance-determining regions (QRDR). The analysis revealed that mutations in gyrA, especially S95T, are prevalent and play a key role in FQ resistance. Additionally, less frequent mutations in gyrB, such as E501D and A533P, were also detected. These findings shed light on the molecular mechanisms contributing to FQ resistance in MDR-TB strains and underscore the need for enhanced diagnostic methods to identify resistance patterns more accurately. The insights gained from this research offer a foundation for improving TB treatment approaches and addressing the growing challenge of drug-resistant TB worldwide. |
| format | Article |
| id | doaj-art-17c3678aec814e388bf22557de1271ae |
| institution | OA Journals |
| issn | 0973-7510 2581-690X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj-art-17c3678aec814e388bf22557de1271ae2025-08-20T01:59:14ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2024-12-0118426512658https://doi.org/10.22207/JPAM.18.4.38Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant TuberculosisAnam Shafiqhttps://orcid.org/0000-0002-3469-1597Haris Manzoor Khanhttps://orcid.org/0009-0008-2269-0256Mohd. Shahidhttps://orcid.org/0000-0002-4684-3607Nazish Fatimahttps://orcid.org/0000-0003-3371-087XMo Ahamad Khanhttps://orcid.org/0000-0002-6866-0035The global tuberculosis (TB) epidemic is becoming progressively more complex due to the increasing prevalence of multidrug-resistant TB (MDR-TB), particularly with resistance to fluoroquinolones (FQs). This study focuses on identifying genetic mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis that drive FQ resistance. Sputum samples from suspected pulmonary TB patients were analyzed using PCR and sequencing to detect mutations within the quinolone resistance-determining regions (QRDR). The analysis revealed that mutations in gyrA, especially S95T, are prevalent and play a key role in FQ resistance. Additionally, less frequent mutations in gyrB, such as E501D and A533P, were also detected. These findings shed light on the molecular mechanisms contributing to FQ resistance in MDR-TB strains and underscore the need for enhanced diagnostic methods to identify resistance patterns more accurately. The insights gained from this research offer a foundation for improving TB treatment approaches and addressing the growing challenge of drug-resistant TB worldwide.https://microbiologyjournal.org/mutational-insights-into-gyra-and-gyrb-genes-in-mycobacterium-tuberculosis-a-genetic-basis-for-fluoroquinolone-resistance-in-multidrug-resistant-tuberculosis/mdr-tbfluoroquinolone resistancegyra mutationsgyrb mutationsdiagnosissequence analysis |
| spellingShingle | Anam Shafiq Haris Manzoor Khan Mohd. Shahid Nazish Fatima Mo Ahamad Khan Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis Journal of Pure and Applied Microbiology mdr-tb fluoroquinolone resistance gyra mutations gyrb mutations diagnosis sequence analysis |
| title | Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis |
| title_full | Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis |
| title_fullStr | Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis |
| title_full_unstemmed | Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis |
| title_short | Mutational Insights into GyrA and GyrB Genes in Mycobacterium tuberculosis: A Genetic Basis for Fluoroquinolone Resistance in Multidrug-resistant Tuberculosis |
| title_sort | mutational insights into gyra and gyrb genes in mycobacterium tuberculosis a genetic basis for fluoroquinolone resistance in multidrug resistant tuberculosis |
| topic | mdr-tb fluoroquinolone resistance gyra mutations gyrb mutations diagnosis sequence analysis |
| url | https://microbiologyjournal.org/mutational-insights-into-gyra-and-gyrb-genes-in-mycobacterium-tuberculosis-a-genetic-basis-for-fluoroquinolone-resistance-in-multidrug-resistant-tuberculosis/ |
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