Multi-targeted, NOT gated CAR-T cells as a strategy to protect normal lineages for blood cancer therapy

Multi-targeted, NOT gated CAR-T cells as a strategy to protect normal lineages for blood cancer therapy

IntroductionDespite advances in treatment of blood cancers, several—including acute myeloid leukemia (AML)—continue to be recalcitrant. Cell therapies based on chimeric antigen receptors (CARs) have emerged as promising approaches for blood cancers. However, current CAR-T treatments suffer from on-t...

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Bibliographic Details
Main Authors: Breanna DiAndreth, Pavlo A. Nesterenko, Aaron G. Winters, Aaron D. Flynn, Claudia A. Jette, Vasantika Suryawanshi, Sanam Shafaattalab, Sara Martire, Mark Daris, Elizabeth Moore, Ryan Elshimali, Tanveer Gill, Timothy P. Riley, Sara Miller, Chawita Netirojjanakul, Agnes E. Hamburger, Alexander Kamb
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
CAR-T cells
CD33
CD16
SPN
AML
LIR-1 (LILRB1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1493329/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1493329/full

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