Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction

Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction

Introduction: Multiple Myeloma (MM) progresses over 2-3 decades through two pre-malignant stages (MGUS and SMM), culminating in clinically active disease. Given the limitations in acquiring sequential bone marrow (BM) samples from patients over this time frame, the mechanisms that compromise immunos...

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Bibliographic Details
Main Authors: Suchita Suryakant Jadhav, Vipin Sharma, Aharon Lion, Lasser-Katz Efrat, Iftach Shaked, Galia Luboshits, Michael A. Firer
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Multiple myeloma
Immune profile
mouse model
MGUS
SMM
T cell exhaustion
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000880
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