Evaluating polygenic risk score prediction performance for Alzheimer's disease in a population-based Hispanic cohort using single- and multi-ancestry modelsResearch in context

Evaluating polygenic risk score prediction performance for Alzheimer's disease in a population-based Hispanic cohort using single- and multi-ancestry modelsResearch in context

Summary: Background: The Polygenic risk score (PRS) is effective in predicting Alzheimer's Disease (AD) risk among Europeans but remains understudied in Hispanics. Genome-wide association studies (GWAS) based on multiple ancestries can improve PRS prediction. We used GWAS data from the largest...

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Main Authors: Yuexuan Xu, Min Qiao, Tamil I. Gunasekaran, Yian Gu, Dolly Reyes-Dumeyer, Angel Piriz, Danurys Sanchez, Belisa Soriano, Yahaira Franco, Zoraida Dominguez Coronado, Patricia Recio, Diones Rivera Mejia, Martin Medrano, Rafael A. Lantigua, Lawrence Honig, Jennifer J. Manly, Adam M. Brickman, Badri N. Vardarajan, Richard Mayeux
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:The Lancet Regional Health. Americas
Subjects:
Polygenic risk score
Caribbean Hispanics
Prediction
Alzheimer's
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2667193X2500208X
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