Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2

Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2

Abstract Background Junctophilin-2 (JPH2) is a vital protein in cardiomyocytes, anchoring T-tubule and sarcoplasmic reticulum membranes to facilitate excitation-contraction coupling, a process essential for cardiac contractile function. Dysfunction of JPH2 is associated with cardiac disorders such a...

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Main Authors: Tianwei Guo, Hongyue Wang, Fujian Wu, Wenjing Lu, Min Zhu, Shuhong Ma, Yongshuai Zhang, Yuting Yan, Meng Zhou, Didaer Talanaite, Siyu Liu, Man Qi, Feng Lan, Xujie Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Junctophilin 2
Excitation-contraction coupling
Cardiomyopathy
Human embryonic stem cell-derived cardiomyocytes
Online Access:https://doi.org/10.1186/s13287-025-04323-4
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https://doi.org/10.1186/s13287-025-04323-4

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