Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation

Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation

Abstract Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosomes-miRNA plays a crucial role in disease progressio...

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Main Authors: Juan Ji, Qian He, Yunfei Xia, Xiaoqi Sha, Qian Liang, Yongxin Xu, Pengyu Chen, Chen Dong, Rui Zhao, Junling Yang, Hua Guo, Yunan Wang, Haixia Cao, Jing Li, Mei Yang, Zhifeng Gu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Systemic lupus erythematosus
Exosomes
miR-122-5p
Macrophages
Online Access:https://doi.org/10.1186/s12951-024-03063-6
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https://doi.org/10.1186/s12951-024-03063-6

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