Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells

Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells

Abstract Heterozygous mutations in GRN gene lead to insufficient levels of the progranulin (PGRN) protein, resulting in frontotemporal dementia (FTD) with TAR DNA-binding protein 43 (TDP-43) inclusions, classified pathologically as frontotemporal lobar degeneration (FTLD-TDP). Homozygous GRN mutatio...

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Bibliographic Details
Main Authors: Katarzyna Gaweda-Walerych, Vanessa Aragona, Simona Lodato, Emilia J. Sitek, Ewa Narożańska, Emanuele Buratti
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Translational Neurodegeneration
Subjects:
Progranulin deficiency
TAR-DNA binding protein 43
Frontotemporal dementia
Primary progressive aphasia
Astrocytes
Microglia
Online Access:https://doi.org/10.1186/s40035-025-00475-8
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https://doi.org/10.1186/s40035-025-00475-8

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