Paris saponin VII attenuates psoriasiform inflammation by regulating STAT3/NFκB signaling pathway and Caspase-1-induced pyroptosis

Paris saponin VII attenuates psoriasiform inflammation by regulating STAT3/NFκB signaling pathway and Caspase-1-induced pyroptosis

Abstract Psoriasis is a significant global health challenge due to limited treatment efficacy. Paris saponin VII (PSVII) shows anti-inflammatory and anti-proliferative potential but its role in psoriasis is unclear. In this study, PSVII was identified from a library of natural compounds as a therape...

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Bibliographic Details
Main Authors: Xiangnan Zhou, Jingyuan Ning, Doudou Wu, Qingwu Liu, Wenbo Jiang, Jiayi Liu, Rui Cai, Diangang Liu, Yanping Bai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Psoriasis
Pyroptosis
STAT3/NFκB signaling pathway
Paris saponin VII
Inflammation
Caspase-1
Online Access:https://doi.org/10.1186/s10020-025-01253-y
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https://doi.org/10.1186/s10020-025-01253-y

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