The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers

The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers

Abstract Homologous recombination deficiency (HRD) is a common characteristic of human cancers, which occurs most frequently in ovarian and breast cancers. The unique genetic vulnerabilities, coupled with the synthetic lethality effect of Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPi), provi...

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Bibliographic Details
Main Authors: Qiuyang Xu, Yuanjia Wen, Taiyuan Huang, Huayi Li, Xingzhe Liu, Shen-nan Shi, Wenjian Gong, Gordon B. Mills, Ding Ma, Qinglei Gao, Yong Fang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biomarker Research
Subjects:
Tumor immune microenvironment
Homologous-recombination deficient
PAPR inhibitor
Immune checkpoint inhibitors
Online Access:https://doi.org/10.1186/s40364-025-00814-x
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https://doi.org/10.1186/s40364-025-00814-x

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