Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells
Abstract The Fc fragment of IgG binding protein (FCGBP) exhibits differential expression across various tumor types. but its role in cancer progression remains underexplored. This research discovered that FCGBP is downregulated in colorectal cancer (CRC) cells and is negatively associated with poor...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13873-y |
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| _version_ | 1850094989147635712 |
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| author | Jiefu Wang Ziqing Gong Jia Liu Wenpeng Wang Kai Liu Yanpeng Yang Xinran Lu Junfeng Wang |
| author_facet | Jiefu Wang Ziqing Gong Jia Liu Wenpeng Wang Kai Liu Yanpeng Yang Xinran Lu Junfeng Wang |
| author_sort | Jiefu Wang |
| collection | DOAJ |
| description | Abstract The Fc fragment of IgG binding protein (FCGBP) exhibits differential expression across various tumor types. but its role in cancer progression remains underexplored. This research discovered that FCGBP is downregulated in colorectal cancer (CRC) cells and is negatively associated with poor prognosis. Overexpression of FCGBP inhibited the growth of P53 wild-type CRC cells both in vitro and in vivo. Mechanistically, immunoprecipitation experiments revealed that FCGBP competitively binds to MDM2, thereby attenuating the formation of the P53/MDM2 complex. This, in turn, reduces P53 ubiquitination and stabilizes the protein. Our findings reveal a novel mechanism through which FCGBP significantly inhibits CRC cell growth and propose a new targeted therapeutic strategy for CRC treatment. |
| format | Article |
| id | doaj-art-174d5ec49542495c849d559a94765fb7 |
| institution | DOAJ |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-174d5ec49542495c849d559a94765fb72025-08-20T02:41:32ZengBMCBMC Cancer1471-24072025-03-012511910.1186/s12885-025-13873-yFc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cellsJiefu Wang0Ziqing Gong1Jia Liu2Wenpeng Wang3Kai Liu4Yanpeng Yang5Xinran Lu6Junfeng Wang7Tianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerPeking University Health Science CenterTianjin’s Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for CancerAbstract The Fc fragment of IgG binding protein (FCGBP) exhibits differential expression across various tumor types. but its role in cancer progression remains underexplored. This research discovered that FCGBP is downregulated in colorectal cancer (CRC) cells and is negatively associated with poor prognosis. Overexpression of FCGBP inhibited the growth of P53 wild-type CRC cells both in vitro and in vivo. Mechanistically, immunoprecipitation experiments revealed that FCGBP competitively binds to MDM2, thereby attenuating the formation of the P53/MDM2 complex. This, in turn, reduces P53 ubiquitination and stabilizes the protein. Our findings reveal a novel mechanism through which FCGBP significantly inhibits CRC cell growth and propose a new targeted therapeutic strategy for CRC treatment.https://doi.org/10.1186/s12885-025-13873-yFc fragment of IgG binding proteinColorectal cancerWild type P53UbiquitinationMDM2 |
| spellingShingle | Jiefu Wang Ziqing Gong Jia Liu Wenpeng Wang Kai Liu Yanpeng Yang Xinran Lu Junfeng Wang Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells BMC Cancer Fc fragment of IgG binding protein Colorectal cancer Wild type P53 Ubiquitination MDM2 |
| title | Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells |
| title_full | Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells |
| title_fullStr | Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells |
| title_full_unstemmed | Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells |
| title_short | Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells |
| title_sort | fc fragment of igg binding protein suppresses tumor growth by stabilizing wild type p53 in colorectal cancer cells |
| topic | Fc fragment of IgG binding protein Colorectal cancer Wild type P53 Ubiquitination MDM2 |
| url | https://doi.org/10.1186/s12885-025-13873-y |
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