Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression

Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression

Age-related macular degeneration (AMD), the leading cause of irreversible blindness worldwide, represents a complex neurodegenerative disorder whose pathogenesis remains elusive. At the core of AMD pathophysiology lies the retinal pigment epithelium (RPE), whose epithelial–mesenchymal transition (EM...

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Bibliographic Details
Main Authors: Na Wang, Yaqi Wang, Lei Zhang, Wenjing Yang, Songbo Fu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
age-related macular degeneration
epithelial–mesenchymal transition
retinal pigment epithelium
oxidative stress
TGF-β
autophagy
Online Access:https://www.mdpi.com/2218-273X/15/6/771
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