The genomic and epigenomic landscape of iridocorneal endothelial syndrome

The genomic and epigenomic landscape of iridocorneal endothelial syndrome

Iridocorneal endothelial (ICE) syndrome is a rare, irreversibly blinding eye disease with an unknown etiology. Understanding its genomic and epigenomic landscape could aid in developing etiology-based therapies. In this study, we recruited 99 ICE patients and performed whole-genome sequencing (WGS)...

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Main Authors: Yaoming Liu, Gen Li, Jiaxuan Jiang, Sujie Fan, Lan Lu, Ting Wang, Guigang Li, Wenzong Zhou, Xuequn Liu, Yingjie Li, Hong Sun, Liang Liang, Yuhong Tang, Yang Chen, Jianjun Gu, Fei Li, Xiuli Fang, Tao Sun, Aiguo Lv, Yayi Wang, Peiyuan Wang, Tao Wen, Jiayu Deng, Yuhong Liu, Mingying Lai, Jingni Yu, Danyan Liu, Hua Wang, Meizhu Chen, Li Li, Xiaodan Huang, Jingming Shi, Xu Zhang, Kang Zhang, Lingyi Liang, Xiulan Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Genes and Diseases
Subjects:
Copy number variance
DNA methylation
Etiology
Iridocorneal endothelial syndrome
Whole-genome sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224002459
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