Inactivation of the Fusobacterium nucleatum Rnf complex reduces FadA-mediated amyloid formation and tumor development

Inactivation of the Fusobacterium nucleatum Rnf complex reduces FadA-mediated amyloid formation and tumor development

ABSTRACT The Gram-negative anaerobe Fusobacterium nucleatum is an oral oncobacterium that promotes colorectal cancer (CRC) development with the amyloid-forming cell surface adhesin FadA integral to CRC tumorigenesis. We describe here molecular genetic studies uncovering a novel mode of metabolic reg...

Full description

Saved in:
Bibliographic Details
Main Authors: Timmie A. Britton, Ju Huck Lee, Chungyu Chang, Aadil H. Bhat, Yi-Wei Chen, Rusul Mohammed Ali, Chenggang Wu, Asis Das, Hung Ton-That
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
Rnf complex
metabolism
two-component system
amyloid
tumor
colorectal cancer
Online Access:https://journals.asm.org/doi/10.1128/mbio.01032-25
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.asm.org/doi/10.1128/mbio.01032-25

Similar Items