The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability

The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability

Abstract Background ATP-dependent nucleosome remodeling complexes of the imitation switch (ISWI) family slide and space nucleosomes. The ISWI ATPase subunit forms obligate complexes with accessory subunits whose mechanistic roles remain poorly understood. In baker’s yeast, the Isw2 ATPase subunit as...

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Bibliographic Details
Main Authors: Ashish Kumar Singh, Sabine Ines Grünert, Lena Pfaller, Felix Mueller-Planitz
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Epigenetics & Chromatin
Subjects:
ISW2
Itc1
WAC domain
Nucleosome remodeler
Nucleosome positioning and spacing
Saccharomyces cerevisiae
Online Access:https://doi.org/10.1186/s13072-025-00593-7
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https://doi.org/10.1186/s13072-025-00593-7

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