DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases

DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases

Abstract Oligonucleotide-based medicine faces challenges in efficiently crossing the blood-brain barrier and rapidly reducing toxic proteins. To address these challenges, here we establish an integrated modality, brain-penetrant DNA nanoflowers incorporated with oligonucleotide-based proteolysis tar...

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Bibliographic Details
Main Authors: Ruixin Ge, Miao Chen, Sijin Wu, Sirui Huang, Ping Zhou, Minghui Cao, Fan Zhang, Jinzhi Zang, Yigao Zhu, Jingrui Li, Guilin Ni, Zhihao Yang, Qingchao Li, Wei Pan, Liang Zhang, Min Liu, Chenghao Xuan, Haiyang Yu, Jun Zhou, Songbo Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60039-2
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https://doi.org/10.1038/s41467-025-60039-2

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