Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma

Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma

The polymerase 1 and transcript release factor (PTRF)–cytoplasmic phospholipase A2 (cPLA2) phospholipid remodeling pathway facilitates tumor proliferation in glioma. Nevertheless, blockade of this pathway leads to the excessive activation of oncogenic receptors on the plasma membrane and subsequent...

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Bibliographic Details
Main Authors: Dongyuan Su, Biao Hong, Shixue Yang, Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kaikai Yi, Yanping Huang, Jiasheng Ju, Eryan Yang, Qixue Wang, Junhu Zhou, Yunfei Wang, Xing Liu, Chunsheng Kang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Glioblastoma
PTRF
cPLA2
DPP4
EGFR
Linagliptin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003181
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