Comparative study on the expression characteristics of transgenes inserted into the Gt(ROSA)26Sor and H11 loci in mice

Comparative study on the expression characteristics of transgenes inserted into the Gt(ROSA)26Sor and H11 loci in mice

The Gt(ROSA)26Sor (ROSA26) and H11 loci are commonly used as safe harbors for the construction of targeted transgenic mice. However, it remains unclear whether these two loci have distinct effects on transgene expression. In this study, we insert three differently colored fluorescent protein express...

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Bibliographic Details
Main Authors: Yu Zhilan, Shi Jiahao, Zhang Jingyu, Wu Youbing, Shen Ruling, Fei Jian
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
transgenic mouse
knockin
<italic>Gt(ROSA)26Sor</italic>
<italic>H11</italic>
gene expression
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024081
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https://www.sciengine.com/doi/10.3724/abbs.2024081

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