The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19

The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19

ABSTRACT Immunocompromised individuals are susceptible to severe coronavirus disease 2019 and potentially contribute to the emergence of variants with altered pathogenicity due to persistent infection. This study investigated the impact of immunosuppression on severe acute respiratory syndrome coron...

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Main Authors: Rebekah Penrice-Randal, Eleanor G. Bentley, Parul Sharma, Adam Kirby, I'ah Donovan-Banfield, Anja Kipar, Daniele F. Mega, Chloe Bramwell, Joanne Sharp, Andrew Owen, Julian A. Hiscox, James P. Stewart
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
COVID-19
immunocompromised
intra-host evolution
molnupiravir
nirmatrelvir
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01829-24
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https://journals.asm.org/doi/10.1128/spectrum.01829-24

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