Circulating myeloid-derived suppressor cell load and disease severity are associated to an enhanced oligodendroglial production in a murine model of multiple sclerosis

Circulating myeloid-derived suppressor cell load and disease severity are associated to an enhanced oligodendroglial production in a murine model of multiple sclerosis

Multiple sclerosis (MS) is a highly heterogeneous immune-mediated demyelinating disease. Myelin restoration is essential to prevent disability progression in MS patients. However, remyelinating therapies are failing in clinical trials, in part, due to the lack of biomarkers that classify the differi...

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Main Authors: Mari Paz Serrano-Regal, Celia Camacho-Toledano, Inmaculada Alonso-García, María Cristina Ortega, Isabel Machín-Díaz, Rafael Lebrón-Galán, Jénnifer García-Arocha, Leticia Calahorra, Manuel Nieto-Díaz, Diego Clemente
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neurobiology of Disease
Subjects:
Myelin
EAE
MDSCs
OPCs
Demyelination
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001354
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