Genetic variation of hemolysin co-regulated protein 1 affects the immunogenicity and pathogenicity of Burkholderia pseudomallei.

Genetic variation of hemolysin co-regulated protein 1 affects the immunogenicity and pathogenicity of Burkholderia pseudomallei.

Hemolysin co-regulated protein 1 (Hcp1) is a component of the cluster 1 Type VI secretion system (T6SS1) that plays a key role during the intracellular lifecycle of Burkholderia pseudomallei. Hcp1 is recognized as a promising target antigen for developing melioidosis diagnostics and vaccines. While...

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Main Authors: Sarunporn Tandhavanant, Thatcha Yimthin, Sineenart Sengyee, Ratana Charoenwattanasatien, Andrey A Lebedev, Eric R Lafontaine, Robert J Hogan, Claire Chewapreecha, T Eoin West, Paul J Brett, Mary N Burtnick, Narisara Chantratita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012758
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https://doi.org/10.1371/journal.pntd.0012758

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