Effects of Betulinic Acid and Ursolic Acid on IL-17-Induced CCL20 Release in Normal Human Epidermal Keratinocytes

Effects of Betulinic Acid and Ursolic Acid on IL-17-Induced CCL20 Release in Normal Human Epidermal Keratinocytes

Psoriasis is a chronic inflammatory skin disease characterized by erythema, infiltration, and scaling, which is mainly caused by interleukin (IL)-17. The use of molecular targeted drugs in specific therapies offers high efficacy; however, high medical costs and a significant risk of side effects hig...

Full description

Saved in:

Bibliographic Details
Main Authors:	Anna Arai, Takahiro Oyama, Toyoaki Nakajima, Michiru Usui, Ena Sato, Takanori Kamiya, Midori Oyama, Takashi Tanikawa, Tomoharu Takeuchi, Takehiko Abe, Tomomi Hatanaka
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Life
Subjects:	psoriasis epidermal keratinocyte betulinic acid ursolic acid interleukin 17 C-C motif chemokine ligand 20
Online Access:	https://www.mdpi.com/2075-1729/15/7/1073
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of Nanoemulsions of Betulinic Acid on the Development of Canine Mammary Tumors
by: Zayra Yeretzi Amoros-Cerón, et al.
Published: (2025-05-01)

Progress of ursolic acid on the regulation of macrophage: summary and prospect
by: Wenjing Feng, et al.
Published: (2025-05-01)

Ursolic acid attenuates beta-amyloid-induced memory impairment in mice
by: Wenna Liang, et al.
Published: (2016-06-01)

Extraction of ursolic acid in Cornus officinalis by fermentation combined with ultrasonic-assisted technique
by: XU Bai-tao, et al.
Published: (2009-05-01)

Zinc Influences the Efficacy of Betulinic Acid Treatment and Radiotherapy in Breast Cancer Cells
by: Antje Güttler, et al.
Published: (2024-10-01)

Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells
by: Sakshi Singh, et al.
Published: (2025-08-01)

Therapeutic potential of ursolic acid (UA) and their derivatives with nanoformulations to combat nosocomial pathogens
by: Umesh Chand, et al.
Published: (2025-03-01)

Effects of Ursolic Acid on Immune Function and Antioxidative Capacity in Weaned Rabbits
by: Yanhua Liu, et al.
Published: (2025-07-01)

EFFECT OF URSOLIC ACID, HYPERINSULINEMIA AND VITAMIN B COMPLEX ON SOME BIOCHEMICAL PARAMETERS AND SKELETAL MUSCLE HISTOLOGY OF ALLOXAN INDUCED DIABETIC RABBITS
by: Shaymae, et al.
Published: (2017-12-01)

Ultraviolet, Did the Cell See It from the Side or the Bottom? Assessment and Modeling of UV Effects on Cultured Cells Using the CL-1000 UV-Crosslinker
by: Takahiro Oyama, et al.
Published: (2024-10-01)

A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical
by: Carlos D. Gutierrez, et al.
Published: (2024-09-01)

Betulinic Acid-Loaded Oleogel as a Novel Pharmaceutical Formulation for Potential Cutaneous Applications: Development, Characterization, and Biosafety Profile
by: Andreea Smeu, et al.
Published: (2025-06-01)

Podophyllotoxin, Deoxypodophyllotoxin and Ursolic Acid as Potential Inhibitors of tcpA, ompW, and ctxB Genes in Vibrio cholerae: An in-Silico Study
by: Yasin SarveAhrabi1*, et al.
Published: (2023-03-01)

Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
by: Sherien M. Bakry, et al.
Published: (2025-04-01)

Effects of ursolic acid on growth performance, serum biochemistry, antioxidant capacity, and intestinal health of broilers
by: X.W. Zhang, et al.
Published: (2025-01-01)

Betulinic Acid Inhibits the Metastasis of Colon Cancer Cells through Regulating TGF-β/Smad Signaling Pathway
by: Xiaoying LIN, et al.
Published: (2020-02-01)

Oral curative therapeutic study of N-nitrosodiethylamine-induced mouse liver damage of chitosan-coated ursolic acid niosomes
by: Andang Miatmoko, et al.
Published: (2025-06-01)

Betulinic Acid ω-Triphenylphosphonium Alkyl Esters: Antiproliferative Activities and In Silico Pharmacokinetic Profiles
by: Cristian Suárez-Rozas, et al.
Published: (2025-06-01)

Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents
by: Olga Michalak, et al.
Published: (2025-08-01)

Protective Effect and Mechanism of Ursolic Acid on Acute Alcoholic Liver Injury in Mice
by: Miao XIAO, et al.
Published: (2025-06-01)

Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects
by: Tianyuan He, et al.
Published: (2025-03-01)

<i>In Vitro</i> Cytotoxicity Assessment of Betulinic Acid Organic Salts on Triple-Negative Breast Cancer Cells
by: Sonia Apostolova, et al.
Published: (2025-01-01)

Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation
by: Junbin Liu, et al.
Published: (2025-07-01)

A new Clonostachys Sp. ZBS49 filamentous fungus with high production of betulinic acid and its inhibitory effect on liver cancer cells
by: Luran Geng, et al.
Published: (2025-06-01)

Enhancing the Pharmacological Properties of Triterpenes Through Acetylation: An Anticancer and Antioxidant Perspective
by: Barbara Bednarczyk-Cwynar, et al.
Published: (2025-06-01)

Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology
by: Xiyun Sun, et al.
Published: (2025-06-01)

Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4/PPARG pathway
by: Ying Deng, et al.
Published: (2025-07-01)

Structural and Functional Characteristics of Betulin Derivatives
by: T. M. Utkina, et al.
Published: (2020-05-01)

Ursolic Acid Induces Multifaceted Defense Responses Against Postharvest Blue Mold Rot in Apple Fruit
by: Chang Shu, et al.
Published: (2025-02-01)

Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice
by: Li Kong, et al.
Published: (2024-05-01)

THE EFFECT OF BETULIN NANOSUSPENSION ON THE QUALITY AND DURATION OF WHEAT BREAD STORAGE
by: N. V. Zavorohina, et al.
Published: (2022-08-01)

Synthesis and antimicrobial activity of new betulin derivatives
by: Agata Serrafi, et al.
Published: (2025-05-01)

Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway
by: Mingkun Liu, et al.
Published: (2025-07-01)

Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
by: Zhou Y, et al.
Published: (2025-08-01)

New Betulin Derivatives in Combination with Rimantadine for Inhibition of Influenza Virus Reproduction
by: O. V. Savinova, et al.
Published: (2020-05-01)

Utilization of ursolic acid methyl ester in the treatment of Streptococcus pyogenes in Nile tilapia, concerning physiological, genetic, immune-oxidative, stress, and neuro-ethological parameters
by: Rewan Abdelaziz, et al.
Published: (2025-07-01)

Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress- and mitochondrial-mediated apoptosis
by: Huiqiong Deng, et al.
Published: (2025-04-01)

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism
by: Manhang Hu, et al.
Published: (2025-05-01)

High efficacy of red light photodynamic therapy with 10 % aminolevulinic acid gel irrespective of the extent of keratinocyte atypia in actinic keratosis – exploratory post-hoc analysis of three pivotal phase III trials
by: E. Bierhoff, et al.
Published: (2024-12-01)

Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high-fat diet
by: Oluwatosin O. Omodara, et al.
Published: (2025-01-01)