Improved Convenient Synthesis of Benzoyl Metronidazole: A Nitroimidazole Antibiotics

An improved, cost-effective, and one-pot method for the synthesis of benzoyl metronidazole was achieved by using N,N′-carbonyldiimidazole as a coupling reagent. Moreover, the byproduct imidazole as the catalyst promoted the reaction. The procedures are simple and suitable to large-scale manufactures...

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Bibliographic Details
Main Authors: Zhi-zhong Wang, Long Wang, Pei Huang
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/937454
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