Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

Abstract Prime editing is a genome engineering tool that allows installation of various small edits with high precision. However, prime editing efficiency and purity can vary widely across different edits, genomic targets, and cell types. Prime editing typically offers more precise editing outcomes...

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Main Authors: Louis C. Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Pei-Pei Hsieh, Salman Mustfa, George Thom, Sandra Wimberger, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59708-z
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https://doi.org/10.1038/s41467-025-59708-z

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