Safety, Tolerability, and Pharmacokinetics of SC1011 (Sufenidone), a Novel Antifibrotic Small Molecule, in Phase 1 Studies in Healthy Subjects

Safety, Tolerability, and Pharmacokinetics of SC1011 (Sufenidone), a Novel Antifibrotic Small Molecule, in Phase 1 Studies in Healthy Subjects

ABSTRACT SC1011 (sufenidone) is a novel pyridone derivative with therapeutic potential for idiopathic pulmonary fibrosis (IPF). Two Phase 1 studies evaluated the safety and pharmacokinetics of single (SAD) and multiple ascending doses (MAD) of SC1011 immediate‐release (IR) and modified‐release (MR)...

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Main Authors: Yun Liu, Xiaoning Chen, Huimin Tang, Fan Jiang, Yaqin Tang, Huijuan Zhu, Yanping Du, Hongjie Qian, Shuyun Liu, Xiaoshu Sun, Bin Zan, Yuexia Zeng, Yun Li, Zhen Ge, Yongguo Li, Zhongqi Yang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Science
Subjects:
a novel pyridone derivative
exposure–adverse event analysis
formulation optimization
idiopathic pulmonary fibrosis
Online Access:https://doi.org/10.1111/cts.70179
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https://doi.org/10.1111/cts.70179

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