Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution.

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution.

Thymus function requires extensive cross-talk between developing T-cells and the thymic epithelium, which consists of cortical and medullary TEC. The transcription factor FOXN1 is the master regulator of TEC differentiation and function, and declining Foxn1 expression with age results in stereotypic...

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Main Authors: Kathy E O'Neill, Nicholas Bredenkamp, Christin Tischner, Harsh J Vaidya, Frances H Stenhouse, C Diana Peddie, Craig S Nowell, Terri Gaskell, C Clare Blackburn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0151666
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https://doi.org/10.1371/journal.pone.0151666

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