Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma

Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma

Abstract Background Glioblastoma (GBM) is a highly lethal malignant intracranial tumor, distinguished from low-grade glioma by histopathological hallmarks such as pseudopalisading cells around necrosis (PAN) and microvascular proliferation (MVP). To date the spatial organization of the molecular and...

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Bibliographic Details
Main Authors: Jiukun Hu, Xiaohan Sa, Yue Yang, Yuwen Han, Jie Wu, Minxuan Sun, Shaheryar Shafi, Nafees Ahmad, Sami Siraj, Jiao Yang, Yuanshuai Zhou
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Glioblastoma
Spatial transcriptomes
Pseudopalisading cells around necrosis
Microvascular proliferation
Endothelial cells
Online Access:https://doi.org/10.1186/s12967-025-06185-z
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https://doi.org/10.1186/s12967-025-06185-z

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