Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathology

Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathology

Abstract There are no approved treatments that slow Parkinson’s disease (PD) progression and therefore it is important to identify novel pathogenic mechanisms that can be targeted. Loss of the epigenetic marker, Tet2 appears to have some beneficial effects in PD models, but the underlying mechanism...

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Main Authors: Emmanuel Quansah, Naman Vatsa, Elizabeth Ensink, Jaycie Brown, Tyce Cave, Miguel Aguileta, Emily Schulz, Allison Lindquist, Carla Gilliland, Jennifer A. Steiner, Martha L. Escobar Galvis, Milda Milčiūtė, Michael X. Henderson, Patrik Brundin, Lena Brundin, Lee L. Marshall, Juozas Gordevicius
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Subjects:
Tet2
Primary cilia
α-synuclein
Parkinson’s disease
Online Access:https://doi.org/10.1186/s40478-025-01988-z
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https://doi.org/10.1186/s40478-025-01988-z

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