Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model

Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model

Despite advances in treating pediatric malignant tumors like SHH-medulloblastoma (SHH-MB), the current standard of care remains surgery followed by chemo- and radiotherapy. This aggressive therapy goes along with a significant morbidity with many long-term side effects, especially in children and ad...

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Bibliographic Details
Main Authors: Christina Krüger, Petros Paplomatas, Naomé Kreuter, Malte Hellwig, Alicia Eckhardt, Christian Conze, Leticia Oliveira-Ferrer, Jacqueline Tischendorf, Vanessa Thaden, Ulrich Schüller, Judith Niesen
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cancer Treatment and Research Communications
Subjects:
Immunotoxin
Antibody fragment
Medulloblastoma
PI3-kinase-inhibitor
Combination therapy
Blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2468294225000863
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http://www.sciencedirect.com/science/article/pii/S2468294225000863

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