Pharmacokinetic/pharma-codynamic study of pralurbactam (FL058) combined with meropenem in a neutropenic murine thigh infection model

Pharmacokinetic/pharma-codynamic study of pralurbactam (FL058) combined with meropenem in a neutropenic murine thigh infection model

IntroductionPralurbactam (FL058) is a novel β-lactamase inhibitor with good inhibitory activity on class A, C, and D β-lactamases. This study aimed to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of pralurbactam/meropenem in a neutropenic murine thigh infection model.MethodsAfte...

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Main Authors: Zhiwei Huang, Wenfang Li, Ruohao Zhang, Yi Li, Xin Li, Xingchen Bian, Shansong Zheng, Xinmei Wang, Ning Zhang, Cong Gao, Beining Guo, Zhenling Wang, Jing Zhang, Xiaojie Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Microbiology
Subjects:
pralurbactam
β-lactamase inhibitor
Klebsiella pneumoniae
Escherichia coli
pharmacokinetic/pharmacodynamic analysis
neutropenic thigh infection model
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1516979/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1516979/full

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