Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.

There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells. Using budding yeast Saccharomyces cerevisiae, peptides derived from the Mitotic Arrest Deficient 2 (Mad2)-binding moti...

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Main Authors: Scott C Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao, Jia-Hua Jhuo, Vivien Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198930/1/pone.0198930.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T171621Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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