Formulation and Characterization of β-Cyclodextrins–Nitazoxanide Inclusion Complexes: Enhanced Solubility, In Vitro Drug Release, and Antiviral Activity in Vero Cells

Formulation and Characterization of β-Cyclodextrins–Nitazoxanide Inclusion Complexes: Enhanced Solubility, In Vitro Drug Release, and Antiviral Activity in Vero Cells

<b>Background/Objectives:</b> Nitazoxanide (NTX) exhibits promising therapeutic potential; its effectiveness is constrained by its low oral bioavailability due to its poor water solubility and limited permeability. <b>Methods:</b> This study focused on developing a complex of...

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Bibliographic Details
Main Authors: Kuppu Sakthi Velu, Sonamuthu Jegatheeswaran, Muhammad Saeed Akhtar, Mohammad Rizwan Khan, Sonaimuthu Mohandoss, Naushad Ahmad
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
β-cyclodextrins
nitazoxanide
inclusion complexes
solubility
in vitro drug release
antiviral activity
Online Access:https://www.mdpi.com/1999-4923/16/12/1494
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