Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration

Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration

Activating angiogenic and immunomodulatory potential of stem cells through optimized cultivation strategies presents significant opportunities for cell-based tissue therapeutics. Among others, hydrogels with tunable chemo-mechanical properties offer optimal 3D environments for stem cell functions. H...

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Bibliographic Details
Main Authors: Yeo Gyun Yun, Soon Chul Heo, Ji-Won Jung, Donghyeon Yeo, Seong-Jin Shin, Khaliunsarnai Tsogtbaatar, Yongsung Hwang, Jung-Hwan Lee, Jun Hee Lee, Hae-Won Kim
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Stem cell therapy
Hydrogels
Mechanics
Mechanotransduction
Ischemic injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003202
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