Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway

Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway

Abstract Objective Free fatty acids (FFA) can increase the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in local tissues and organs. However, the mechanism underlying the effect of FFA on 11β-HSD1 expression remains unclear. Methods A total of 24 male Syrian golden hamsters (SPF grade...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang, Guangyao Song
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	Lipids in Health and Disease
Subjects:	Free fatty acids 11β-hydroxysteroid dehydrogenase 1 Endoplasmic reticulum stress CCAAT/enhancer-binding protein homologous protein CCAAT/enhancer-binding protein α Corticosterone
Online Access:	https://doi.org/10.1186/s12944-025-02461-5
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head
by: Peng Zhang, et al.
Published: (2025-01-01)

Ferroptosis-Related Transcriptional Level Changes and the Role of CIRBP in Glioblastoma Cells Ferroptosis
by: Zijiang Yang, et al.
Published: (2024-12-01)

CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa
by: Samantha Verónica González-Téllez, et al.
Published: (2025-01-01)

Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases
by: Jiao Lv, et al.
Published: (2025-01-01)

Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method
by: Cassandra Yun, et al.
Published: (2025-01-01)

Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins
by: Andrew Z. Ma, et al.
Published: (2025-02-01)

Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
by: Yoshimichi Takeda, et al.
Published: (2024-03-01)

Metal-free production of natural blue colorants through anthocyanin–protein interactions
by: Wenxin Wang, et al.
Published: (2025-02-01)

A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide
by: Angelo Santoro, et al.
Published: (2025-01-01)

EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes
by: Qi Zhang, et al.
Published: (2025-01-01)

Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the influence of chloroquine
by: Graziela Vieira Cavalcanti, et al.
Published: (2025-01-01)

Purification, Physicochemical Properties, and Epitope Analysis of Sarcoplasmic Calcium-Binding Protein from Penaeus vannamei
by: CHEN Wei, ZHOU Junjun, CHEN Yachun, JIA Yingmin, MA Aijin
Published: (2025-01-01)

Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model
by: Suresh Kumar
Published: (2017-12-01)

Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene
by: O. V. Arkova, et al.
Published: (2016-01-01)

Candidate antirheumatic genotherapeutic plasmid constructions have low immunogenicity
by: T. S. Nepomnyashchikh, et al.
Published: (2017-05-01)

Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers
by: Shiyi Yu, et al.
Published: (2025-01-01)

Host RNA-Binding Proteins as Regulators of HIV-1 Replication
by: Sebastian Giraldo-Ocampo, et al.
Published: (2024-12-01)

A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception
by: Amber Dyson, et al.
Published: (2025-01-01)

Machine learning approaches for predicting protein-ligand binding sites from sequence data
by: Orhun Vural, et al.
Published: (2025-02-01)

Identification of potential geosmin-binding proteins in grass carp gill based on affinity responsive target stability and tandem mass tag proteomics
by: Jun-ming Zhang, et al.
Published: (2025-02-01)

Comparison of Vitamin-D binding protein levels in gingival crevicular fluid of pre- and postmenopausal women with and without chronic periodontitis: A clinico-biochemical study
by: Kaviya Balasubramaniyam, et al.
Published: (2023-07-01)

The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease
by: Jonathan Feicht, et al.
Published: (2024-12-01)

Prediction of drug-drug plasma protein binding interactions of resveratrol in combination with celecoxib and leflunomide by molecular docking combined with an ultrafiltration technique
by: Zhou Peng, et al.
Published: (2020-03-01)

Acute phase responses in clinically healthy multiparous Holsteins with and without calcium dysregulation during the early postpartum period
by: J.A. Seminara, et al.
Published: (2025-02-01)

Molecular epidemiology and genetic diversity of disappearing Plasmodium vivax in southern Thailand
by: Parsakorn Tapaopong, et al.
Published: (2025-01-01)

Intracellular Membrane Contact Sites in Skeletal Muscle Cells
by: Matteo Serano, et al.
Published: (2025-01-01)

Halo-RPD: searching for RNA-binding protein targets in plants
by: A. O. Shamustakimova
Published: (2024-03-01)

RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis
by: Sheng Chen, et al.
Published: (2025-01-01)

Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis
by: Nese Caglayan, et al.
Published: (2025-02-01)

Potential pathogenic and protective genotypes and phenotypes of vitamin D binding protein in multiple sclerosis
by: Suhail Al-Shammri, et al.
Published: (2025-02-01)

Deodorization of Egg White Powder by Ozone Treatment and Underlying Mechanism
by: XIN Xiaojuan, LIU Ying, MA Lulu, HUO Jiaying, GAO Ying, DONG Shijian, LIU Liya, WANG Fengzhong, LI Shugang
Published: (2024-12-01)

CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis
by: M. Eugenia Delgado, et al.
Published: (2025-03-01)

Unbiased picture of the ligand docking process for the hevein protein–oligosaccharide complex
by: Toshifumi Yui, et al.
Published: (2025-01-01)

The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster
by: E. U. Bolobolova, et al.
Published: (2017-11-01)

Interrelationships of the Intestinal Microbiome, Trimethylamine N-Oxide and Lipopolysaccharide-Binding Protein with Crohn’s Disease Activity
by: Yelena Laryushina, et al.
Published: (2024-12-01)

Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary
by: Kensuke Hamada, et al.
Published: (2025-01-01)

Effects of Seaweed Polysaccharide on the Growth and Physiological Health of Largemouth Bass, <i>Micropterus salmoides</i>
by: Dongyu Huang, et al.
Published: (2025-01-01)

THE MAIN PROPERTIES AND EVOLUTIONARY FEATURES OF ANTIFREEZE PROTEINS
by: L. L. Bildanova, et al.
Published: (2014-12-01)

Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UPR-ERAD pathway
by: Huang Chengrong, et al.
Published: (2025-02-01)

Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients
by: Shawnm Ahmed Aziz
Published: (2020-12-01)