PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells

PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells

ABSTRACT Background The Ets‐1 transcription factor plays a primordial role in regulating the expression of numerous genes implicated in cancer progression. In a previous study, we revealed that poly(ADP‐ribose) polymerase‐1 (PARP‐1) inhibition by PJ‐34 results in Ets‐1 level increase in cells, which...

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Main Authors: Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Cancer Reports
Subjects:
breast cancer cells
DNA damage
Ets‐1 transcription factor
oxidative stress
PARP‐1 inhibitors
Online Access:https://doi.org/10.1002/cnr2.70119
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https://doi.org/10.1002/cnr2.70119

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