Operationalizing postmortem pathology-MRI association studies in Alzheimer’s disease and related disorders with MRI-guided histology sampling

Operationalizing postmortem pathology-MRI association studies in Alzheimer’s disease and related disorders with MRI-guided histology sampling

Abstract Postmortem neuropathological examination, while the gold standard for diagnosing neurodegenerative diseases, often relies on limited regional sampling that may miss critical areas affected by Alzheimer’s disease and related disorders. Ultra-high resolution postmortem MRI can help identify r...

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Main Authors: Chinmayee Athalye, Alejandra Bahena, Pulkit Khandelwal, Sheina Emrani, Winifred Trotman, Lisa M. Levorse, Zahra Khodakarami, Daniel T. Ohm, Eric Teunissen-Bermeo, Noah Capp, Shokufeh Sadaghiani, Sanaz Arezoumandan, Sydney A. Lim, Karthik Prabhakaran, Ranjit Ittyerah, John L. Robinson, Theresa Schuck, Edward B. Lee, M. Dylan Tisdall, Sandhitsu R. Das, David A. Wolk, David J. Irwin, Paul A. Yushkevich
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Postmortem imaging
Histology
Quantitative pathology
MRI-histology registration
Online Access:https://doi.org/10.1186/s40478-025-02030-y
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https://doi.org/10.1186/s40478-025-02030-y

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