miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia

miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia

Abstract Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutic approaches being investigated, no significant clinical benefits have been observed yet. Und...

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Bibliographic Details
Main Authors: Alan J. Keane, Clara Sanz-Nogués, Dulan Jayasooriya, Michael Creane, Xizhe Chen, Caomhán J. Lyons, Isha Sikri, Katarzyna Goljanek-Whysall, Timothy O’Brien
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Chronic limb-threatening ischaemia
Fibrosis
Muscle regeneration
MicroRNAs
Online Access:https://doi.org/10.1038/s41598-024-76415-9
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https://doi.org/10.1038/s41598-024-76415-9

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