A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female
Monoclonal gammopathy of renal significance (MGRS) is a rare disorder in which monoclonal immunoglobulin secreted by nonmalignant B cell or plasma cell clone causes kidney damage. Although MGRS is a premalignant condition, it can cause severe kidney disease and end-stage renal disease (ESRD) at any...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/2497380 |
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| author | Ayrton Bangolo Mahabuba Akhter Amer Jarri Manpreet Kaur Ali Atoot Parul Jandir Mahmood Ibrahim Lochana Manandhar Adam Atoot |
| author_facet | Ayrton Bangolo Mahabuba Akhter Amer Jarri Manpreet Kaur Ali Atoot Parul Jandir Mahmood Ibrahim Lochana Manandhar Adam Atoot |
| author_sort | Ayrton Bangolo |
| collection | DOAJ |
| description | Monoclonal gammopathy of renal significance (MGRS) is a rare disorder in which monoclonal immunoglobulin secreted by nonmalignant B cell or plasma cell clone causes kidney damage. Although MGRS is a premalignant condition, it can cause severe kidney disease and end-stage renal disease (ESRD) at any age. Herein, we present a 31-year-old female with past medical history of lupus nephritis who presented with signs of volume overload and worsening renal function despite adequate immunosuppressive therapy. Renal biopsy revealed heavy and light chain deposition consistent with MGRS. This case report demonstrates the importance of including MGRS in the differential diagnosis of worsening renal function despite adequate treatment, raising awareness of this premalignant yet morbid condition. |
| format | Article |
| id | doaj-art-166167e7040f420db0c08cd06caa3430 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-166167e7040f420db0c08cd06caa34302025-02-03T05:50:02ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/2497380A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old FemaleAyrton Bangolo0Mahabuba Akhter1Amer Jarri2Manpreet Kaur3Ali Atoot4Parul Jandir5Mahmood Ibrahim6Lochana Manandhar7Adam Atoot8HackensackHackensackHackensackHackensackHackensack University Medical CenterHackensackHackensackHackensack Meridian Health Palisades Medical CenterHackensackMonoclonal gammopathy of renal significance (MGRS) is a rare disorder in which monoclonal immunoglobulin secreted by nonmalignant B cell or plasma cell clone causes kidney damage. Although MGRS is a premalignant condition, it can cause severe kidney disease and end-stage renal disease (ESRD) at any age. Herein, we present a 31-year-old female with past medical history of lupus nephritis who presented with signs of volume overload and worsening renal function despite adequate immunosuppressive therapy. Renal biopsy revealed heavy and light chain deposition consistent with MGRS. This case report demonstrates the importance of including MGRS in the differential diagnosis of worsening renal function despite adequate treatment, raising awareness of this premalignant yet morbid condition.http://dx.doi.org/10.1155/2022/2497380 |
| spellingShingle | Ayrton Bangolo Mahabuba Akhter Amer Jarri Manpreet Kaur Ali Atoot Parul Jandir Mahmood Ibrahim Lochana Manandhar Adam Atoot A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female Case Reports in Hematology |
| title | A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female |
| title_full | A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female |
| title_fullStr | A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female |
| title_full_unstemmed | A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female |
| title_short | A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female |
| title_sort | case report of premalignant plasma cell dyscrasia induced renal failure in a 31 year old female |
| url | http://dx.doi.org/10.1155/2022/2497380 |
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