Prevalence of epsilon toxin-producing Clostridium perfringens isolates among patients with multiple sclerosis and neuromyelitis optica spectrum disorder in Iran

Prevalence of epsilon toxin-producing Clostridium perfringens isolates among patients with multiple sclerosis and neuromyelitis optica spectrum disorder in Iran

Abstract Background Clostridium perfringens epsilon toxin (ETX) is a potent neurotoxin that crosses the blood-brain barrier (BBB), and has been suggested to be involved in demyelinating CNS disorders. Here, we investigated the prevalence of C. perfringens and anti-ETX immunoglobulin G (IgG) and immu...

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Main Authors: Masoumeh Azimirad, Sara Hamtaeigashti, Hamideh Raeisi, Mehdi Azizmohammad Looha, Fatemeh Gholami, Abdorreza Naser Moghadasi, Mohammad Reza Zali, Abbas Yadegar
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Neurology
Subjects:
Clostridium perfringens
Epsilon toxin
Multiple sclerosis
Neuromyelitis optica
NMOSD
ETX
Online Access:https://doi.org/10.1186/s12883-025-04251-z
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https://doi.org/10.1186/s12883-025-04251-z

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