Mechanisms and clinical translation of ICOS/ICOSL signaling pathway blockade in delaying vascular complications of type 2 diabetes

Mechanisms and clinical translation of ICOS/ICOSL signaling pathway blockade in delaying vascular complications of type 2 diabetes

Abstract Background Type 2 diabetes mellitus (T2DM) is often complicated by vascular conditions such as atherosclerosis, which contribute significantly to morbidity and mortality. The ICOS/ICOSL signaling pathway has emerged as a promising target for mitigating these complications. This study aims t...

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Bibliographic Details
Main Authors: Haiyan Zhang, LiBo Ruan, Xuemei Fu, Jinwen Yu, Qingrong Ruan, Yiyu Li, Hongying Wang, Heng Shao, Haoran Dong, Jianglan Cui
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Diabetology & Metabolic Syndrome
Subjects:
ICOS/ICOSL signaling
Type 2 diabetes
Atherosclerosis
Vascular complications
Online Access:https://doi.org/10.1186/s13098-025-01891-6
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https://doi.org/10.1186/s13098-025-01891-6

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