Small but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis

Small but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis

ABSTRACT Cryptococcal meningoencephalitis (CME) is deadly. CME is responsible for 19% of deaths in AIDS patients, and its global mortality is greater than 60%. The recommended CME therapy requires amphotericin B (AmB), a fungicidal drug targeting fungal ergosterol. AmB also binds to the host’s chole...

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Bibliographic Details
Main Authors: Tuyetnhu Pham, Peter Zhang, Suresh Ambati, Richard B. Meagher, Xiaorong Lin
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mBio
Subjects:
targeted drug delivery
liposome
dectins
Cryptococcus neoformans
amphotericin B
cryptococcal meningoencephalitis
Online Access:https://journals.asm.org/doi/10.1128/mbio.02507-24
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https://journals.asm.org/doi/10.1128/mbio.02507-24

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