Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow Rates on the Anterior Communicating Artery Bifurcation: A Computational Fluid Dynamics Study
Computational fluid dynamics techniques were used to investigate the hemodynamic effect of unequal anterior cerebral artery flow rates on the anterior cerebral and anterior communicating artery (ACA-ACOM) bifurcation. Hemodynamics have long been implicated as a major factor in cerebrovascular diseas...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Modelling and Simulation in Engineering |
| Online Access: | http://dx.doi.org/10.1155/2008/691982 |
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| author | Thomas Rau Xing He Prem Venugopal Fernando Viñuela Gary Duckwiler Daniel J. Valentino |
| author_facet | Thomas Rau Xing He Prem Venugopal Fernando Viñuela Gary Duckwiler Daniel J. Valentino |
| author_sort | Thomas Rau |
| collection | DOAJ |
| description | Computational fluid dynamics techniques were used to investigate the hemodynamic effect
of unequal anterior cerebral artery flow rates on the anterior cerebral and anterior communicating
artery (ACA-ACOM) bifurcation. Hemodynamics have long been implicated as a major
factor in cerebrovascular disease. Using an idealized 2D symmetric model of the ACA-ACOM
geometry, the flow field and wall shear stress (WSS) at the bifurcation regions are assessed
for pulsatile inflows with left to right flow ratios of 1:1, 2:1, 3:1, and 4:1. Unequal flow rates
through the ACA parent arteries result in bifurcation of the higher flow parent stream and a
shifting of the impingement points along the A2-ACOM adjoining wall toward the contralateral ACA. Cross-flow through the ACOM is generally unstable and results in increased WSS
at the impingement region from the higher flow parent artery and a double amplitude peak
in the WSS at the contralateral bifurcation region from local recirculation effects. These results
suggest that asymmetry in ACA flow rates result in increased hemodynamic stresses at the ACA-ACOM bifurcation regions and suggest a possible factor for vessel weakening and
aneurysm formation. |
| format | Article |
| id | doaj-art-16178167626447a3b00591464ef43a34 |
| institution | Kabale University |
| issn | 1687-5591 1687-5605 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Modelling and Simulation in Engineering |
| spelling | doaj-art-16178167626447a3b00591464ef43a342025-02-03T01:21:25ZengWileyModelling and Simulation in Engineering1687-55911687-56052008-01-01200810.1155/2008/691982691982Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow Rates on the Anterior Communicating Artery Bifurcation: A Computational Fluid Dynamics StudyThomas Rau0Xing He1Prem Venugopal2Fernando Viñuela3Gary Duckwiler4Daniel J. Valentino5Department of Radiology, University of Colorado Health Sciences Center, Aurora, CO 80045, USADepartment of Radiological Sciences, University of California, Los Angeles, CA 90095, USADepartment of Radiological Sciences, University of California, Los Angeles, CA 90095, USADepartment of Radiological Sciences, University of California, Los Angeles, CA 90095, USADepartment of Radiological Sciences, University of California, Los Angeles, CA 90095, USADepartment of Radiological Sciences, University of California, Los Angeles, CA 90095, USAComputational fluid dynamics techniques were used to investigate the hemodynamic effect of unequal anterior cerebral artery flow rates on the anterior cerebral and anterior communicating artery (ACA-ACOM) bifurcation. Hemodynamics have long been implicated as a major factor in cerebrovascular disease. Using an idealized 2D symmetric model of the ACA-ACOM geometry, the flow field and wall shear stress (WSS) at the bifurcation regions are assessed for pulsatile inflows with left to right flow ratios of 1:1, 2:1, 3:1, and 4:1. Unequal flow rates through the ACA parent arteries result in bifurcation of the higher flow parent stream and a shifting of the impingement points along the A2-ACOM adjoining wall toward the contralateral ACA. Cross-flow through the ACOM is generally unstable and results in increased WSS at the impingement region from the higher flow parent artery and a double amplitude peak in the WSS at the contralateral bifurcation region from local recirculation effects. These results suggest that asymmetry in ACA flow rates result in increased hemodynamic stresses at the ACA-ACOM bifurcation regions and suggest a possible factor for vessel weakening and aneurysm formation.http://dx.doi.org/10.1155/2008/691982 |
| spellingShingle | Thomas Rau Xing He Prem Venugopal Fernando Viñuela Gary Duckwiler Daniel J. Valentino Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow Rates on the Anterior Communicating Artery Bifurcation: A Computational Fluid Dynamics Study Modelling and Simulation in Engineering |
| title | Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow
Rates on the Anterior Communicating Artery Bifurcation: A Computational
Fluid Dynamics Study |
| title_full | Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow
Rates on the Anterior Communicating Artery Bifurcation: A Computational
Fluid Dynamics Study |
| title_fullStr | Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow
Rates on the Anterior Communicating Artery Bifurcation: A Computational
Fluid Dynamics Study |
| title_full_unstemmed | Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow
Rates on the Anterior Communicating Artery Bifurcation: A Computational
Fluid Dynamics Study |
| title_short | Hemodynamic Effect of Unequal Anterior Cerebral Artery Flow
Rates on the Anterior Communicating Artery Bifurcation: A Computational
Fluid Dynamics Study |
| title_sort | hemodynamic effect of unequal anterior cerebral artery flow rates on the anterior communicating artery bifurcation a computational fluid dynamics study |
| url | http://dx.doi.org/10.1155/2008/691982 |
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