Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering

Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering

Abstract Noroviruses are non-enveloped, single-stranded positive-sense RNA viruses and the leading cause of gastroenteritis worldwide. The major capsid protein, VP1, can self-assemble into non-infectious virus-like particles (VLPs), representing an attractive vaccine platform. It was demonstrated th...

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Main Authors: Christopher Warren, Jennifer D. Galli, Karin Bystol, Gregory O’Donnell, Andrew R. Swartz, Emily A. Dewar, Corey May Fulton, Pamela Shen, Estibaliz Gonzalez-Fernandez, Lizzy Aurora DeWitt, Uijin Jeong, Oscar Chi-Chien Pan, Sean Miller, Arthur Fridman, Courtney David, Zhifeng Chen, Jiajie Wei
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01254-2
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https://doi.org/10.1038/s41541-025-01254-2

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