New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease

Abstract Exercise offers neuroprotective benefits in Parkinson’s disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mit...

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Bibliographic Details
Main Authors: Xingyue Chen, Guoxin Zhang, Miao Liu, Juanfeng He, Zhentao Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01113-w
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