EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Abstract Genotoxic therapies such as ionizing radiation eliminate cancer cells by inducing extensive DNA damage but often cause normal tissue toxicity, including cutaneous injury. Extrachromosomal circular DNA (eccDNA) refers to circular DNA fragments outside the chromosomal context, with their form...

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Bibliographic Details
Main Authors: Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
circle‐Seq
extrachromosomal circular DNA
genotoxic stress
radiation‐induced skin injury
vacuolar protein sorting 41 homolog (VPS41)
Online Access:https://doi.org/10.1002/advs.202501934
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https://doi.org/10.1002/advs.202501934

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